Study of Pembrolizumab and Radiation Therapy in Liver Cancer

Official Title

Pembrolizumab and Stereotactic Radiation Therapy Combined in Subjects With Advanced Hepatocellular Carcinoma - A Phase II Study


This is a phase 2 study whose purpose is to assess the efficacy of the combination of pembrolizumab and stereotactic body radiation therapy (SBRT) in patients with advanced hepatocellular carcinoma (HCC) who have experienced disease progression after treatment with sorafenib.

Trial Description

Primary Outcome:

  • Overall response rate
Secondary Outcome:
  • Response rate in non-irradiated tumour lesions
  • Progression-free survival rate
  • Overall survival rate

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society