Study of Biomarkers in Gynecological Cancers

Official Title

Molecular and Immunological Characterization of Gynecological Malignancies


In recent years, there has been a significant improvement in understanding the biology of cancer and this information has been used to improve cancer care and patient outcome. Research has shown that changes in some genes and/or proteins may be important indicators for certain cancers and response to treatments. Genes are molecules made up of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). DNA contain instructions for the development and functioning of the cells in the body and are passed down from parent to child. RNA is involved with producing proteins in the body. Further research is needed to better understand the changes found in cancer cells and how to target them to stop or reduce cancer growth. A drug that may be able to block certain specific cancer cell changes is called "targeted therapy". Different people with the same type of cancer receiving the same drug could have different responses to it. For example, one person may experience a reduction of their tumour while another person's cancer may worsen. The reason for this is still not well understood and could lie in gene changes. Understanding these changes may allow researchers to predict how treatments may work in guiding decisions around choice of drugs. The purpose of the study is to learn more about gene changes or protein expression (levels) of tumours to better understand the behaviour of gynecological diseases and, if possible, better address participants' cancer care now or in the future.

Trial Description

Primary Outcome:

  • Genomic and immune signatures in terms of progression free survival
  • Genomic and immune signatures in terms of overall survival

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society