Circulating Tumour DNA in Soft Tissue Sarcoma

Titre officiel

Circulating Tumour DNA Detection in Soft Tissue Sarcoma (DNA-TSAR)

Sommaire:

Lors de cette étude de recherche, on prélèvera des échantillons de sang et de tissu tumoral chez des patients atteints d’un sarcome des tissus mous pour examiner l’acide désoxyribonucléique (ADN) tumoral circulant. Lorsque les cellules tumorales sont endommagées ou meurent, leur ADN passe dans la circulation sanguine à mesure que les cellules se décomposent. C’est ce qu’on appelle l’ADN tumoral circulant. Il s’agit d’un biomarqueur important qui peut être utilisé pour détecter le cancer, prévoir la réponse au traitement et suivre l’évolution de la maladie.

Description de l'essai

Primary Outcome:

  • Number of patients with demonstrable circulating tumour DNA (ctDNA) quantification
Secondary Outcome:
  • Number of patients with demonstrable ctDNA quantification with no pre-op tumour burden, necrosis at surgery, or disease recurrence
Researchers are continually looking for ways to understand the biology of cancer such as sarcoma, and ways to improve cancer care and patient outcome. Research has shown that changes in some genes and/or proteins, called biomarkers, may be important indicators for certain cancers and response to treatments. Genes are molecules made up of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). DNA contain instructions for the development and functioning of the cells in the body and are passed down from parent to child. RNA is involved with producing proteins in the body. Further research is needed to better understand the changes found in cancer cells and what this means for certain treatments. Circulating tumour DNA is an important biomarker that may be used in cancer detection, prediction of treatment response and disease monitoring. When tumour cells are damaged or die, DNA from the tumour cells are released into the blood stream as the cells break down. This is called circulating tumour DNA. Researchers are looking for better ways to detect circulating tumour DNA so that it can be studied. The purpose of this study is to determine how feasible it is to detect circulating tumour DNA in blood samples of soft tissue sarcoma patients and whether there is a connection between circulating tumour DNA and the likelihood of patients' disease coming back after they receive treatment. To do this, blood and tumour tissue samples will be collected from participants and will undergo DNA testing (reading the contents of their DNA, called sequencing). The results of the DNA testing in the blood samples will be compared with the results from DNA testing that will also be done on tumour tissue. The results will also be compared with participant's response to their treatment, recurrence, and/or long term survival.

Voir cet essai sur ClinicalTrials.gov

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