De-Escalation Radiation Therapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma

Official Title

A Phase II Single Arm Trial of Elective Volume Adjusted De-Escalation Radiation Therapy (EVADER) in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma

Summary:

The purpose of this study is to find out whether radiation therapy to some of the lymph node areas can be safely omitted to decrease side effects without increasing the risk of the tumour coming back.

Trial Description

Primary Outcome:

• Event-free Survival

Secondary Outcome:

• Overall Survival
• Local control
• Regional Control
• Locoregional control
• Distant Metastasis-Free Survival

The standard or usual treatment for this disease includes radiation therapy or radiation therapy combined with chemotherapy or antibody therapy. These treatments are highly effective at curing most patients with HPV-related cancer of the oropharynx, but short and long-term side effects from treatment can be significant.

View this trial on ClinicalTrials.gov