Phase I Study of the Wee 1 Kinase (Wee 1) Inhibitor MK-1775 in Combination With Cisplatin and Radiation in Cervical Cancer
This is a phase 1 study to find the best dose of a new investigational drug MK-1775 as well as to see how safe the drug is in combination with cisplatin and radiation in patients with cervical cancer. MK-1775 is a new drug which may block Wee1 protein activity. When given in combination with cisplatin and radiation therapy, MK-1775 may help prevent the Wee1 protein from repairing damaged tumour cells without causing harm to normal cells. This is believed to increase the effectiveness of cisplatin and radiation therapy.
Primary Outcome:
View this trial on ClinicalTrials.gov
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These resources are provided in partnership with the Canadian Cancer Society