Major Radiation Reduction for HPV+ Oropharyngeal Carcinoma

Official Title

A Prospective Non-inferiority Trial of Major Radiation Dose De-Escalation Concurrent With Chemotherapy for Human Papilloma Virus Associated Oropharyngeal Carcinoma


The purpose of this study is to demonstrate that participants with HPV positive and hypoxia negative T1-2N / 1-2b oropharyngeal squamous cell carcinoma receiving a major de-escalated radiation therapy with 2 cycles of standard chemotherapy is not inferior to comparable subjects treated with the current standard chemoradiation.

Trial Description

Primary Outcome:

  • Effectiveness of study treatment for participants receiving de-escalated radiation therapy radiation therapy, comparable to participants treated with the current standard of care chemoradiation by standard CT (or MRI) or tumour site and PET scan

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Canadian Cancer Society

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