Major Radiation Reduction for HPV+ Oropharyngeal Carcinoma

Official Title

A Prospective Non-inferiority Trial of Major Radiation Dose De-Escalation Concurrent With Chemotherapy for Human Papilloma Virus Associated Oropharyngeal Carcinoma

Summary:

The purpose of this study is to demonstrate that participants with HPV positive and hypoxia negative T1-2N / 1-2b oropharyngeal squamous cell carcinoma receiving a major de-escalated radiation therapy with 2 cycles of standard chemotherapy is not inferior to comparable subjects treated with the current standard chemoradiation.

Trial Description

Primary Outcome:

• Effectiveness of study treatment for participants receiving de-escalated radiation therapy radiation therapy, comparable to participants treated with the current standard of care chemoradiation by standard CT (or MRI) or tumour site and PET scan

View this trial on ClinicalTrials.gov