Prehabilitation to Improve Cancer Surgery Outcomes

Official Title

Prehabilitation to Improve Cancer Surgery Outcomes (PICaSO): A Randomized Controlled Trial


This is a randomized control trial aiming to investigate the use of a prehabilitation regimen for patients undergoing major GI cancer surgery and its effects on measurements of HRQOL, LOS, and post-operative complications. Participants will be randomized to either the Prehabilitation arm or the Usual Care arm (control group). The Prehabilitation arm will be prescribed both physical and psychological prehabilitation prior to undergoing surgery for their GI cancer. The Usual Care arm will be counseled to continue their current level of activity and given the information on exercise as outlined in the Cancer Care Ontario guidelines. Participants in the Usual Care arm will also be given the same activity tracker as patients in the Prehabilitation arm in order to eliminate the activity tracker as an intervention itself. Clinical, patient-reported outcomes and health system outcomes will be evaluated. Outcomes will be measured at consent (baseline), immediately preoperatively, and postoperatively at 1, 3 and 6 months. The investigators will collect measures of recruitment, attrition and self-reported compliance via a log completed by the coordinator during weekly patient phone calls.

Trial Description

Primary Outcome:

  • Global Health Score
Secondary Outcome:
  • Presence and severity of postoperative complications
  • Postoperative hospital length of stay
  • Changes in functional capacity from baseline
  • Changes in self-reported physical activity from baseline
  • Changes in health-related quality of life from baseline
  • Presence and severity of symptoms
  • Changes in anxiety and depression from baseline
  • Changes in fatigue from baseline
  • Interference with occupational performance and productivity
  • Changes in multidimensional social support
  • Changes in attachment (closeness in relationships with others)
  • Health care utilization

View this trial on

Interested in this trial?

Print this page and take it to your doctor to discuss your eligibilty and treatment options. Only your doctor can refer you to a clinical trial.


Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society