Ventilation Heterogeneity Prior to Lung Resection

Official Title

Prevalence and Clinical Relevance of Ventilation Heterogeneity and Luminal Cellular Inflammation in Lung Cancer Patients Prior to Lung Resection

Summary:

This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed tomography (V SPECT) and hyperpolarized 129Xe magnetic resonance imaging (MRI)), in the presence or absence of airway inflammation (assessed by sputum cell counts), in lung cancer patients prior to lung resection surgery.

Trial Description

Primary Outcome:

• Abnormal ventilation heterogeneity assessed by Technegas V SPECT
• Abnormal ventilation heterogeneity assessed by 129Xe MRI

• Technegas V SPECT ventilation heterogeneity and luminal cellular inflammation
• 129Xe MRI ventilation heterogeneity and luminal cellular inflammation
• Incidence of post-operative pulmonary complications (PPC): Technegas V SPECT ventilation heterogeneity
• Incidence of PPC: 129Xe MRI ventilation heterogeneity
• Incidence of PPC: Technegas V SPECT ventilation heterogeneity and luminal cellular inflammation
• Incidence of PPC: 129Xe MRI ventilation heterogeneity and luminal cellular inflammation

View this trial on ClinicalTrials.gov