Integrated Patient Avatars for Guiding Systemic Therapy Treatments in Metastatic Breast Cancer Patients

Titre officiel

Integrated Patient Avatars for Guiding Systemic Therapy Treatments: "Intuition-Free" Decisions in Metastatic Breast Cancer Patients

Sommaire:

Les chercheurs proposent d’utiliser une technologie d’avatar de patient validée cliniquement (« PDXovo ») qui peut tester plusieurs médicaments contre les cancers des patients afin de définir le traitement à action générale le plus prometteur pour chaque individu.

Description de l'essai

Primary Outcome:

• Determine the tumour take rate in PDX

Secondary Outcome:

• Compare response rates of PDXs & with that of the patient from whom the PDX was derived

The primary goal of this feasibility study is to determine the percentage of patients for whom PDXs are successfully generated within 7-10 days. This will give the investigators an indication of the success rate for providing patients with actionable information if this PDX technology were to be implemented in the clinic. Since the PDXs will also receive the same drug as the patient, there is an opportunity to assess the agreement between the clinical response and the PDX response. As a secondary goal, the response of PDXs will be compared to the patient's response to systemic therapy, as measured using the objective response rate at 12 weeks +/- 4 weeks (ORR, measured using RECIST 1.1 criteria).

Voir cet essai sur ClinicalTrials.gov