Exercise and Cognitive (Brain) Function in Breast Cancer Patients Getting Chemotherapy After Breast Surgery

Titre officiel

Cardiorespiratory Fitness, Inflammatory Biomarkers, and Cognitive Function Patterns During Treatment for Breast Cancer: A Prospective Cohort Study


Cette étude permettra principalement de déterminer des associations longitudinales entre la capacité cardiorespiratoire et la fonction cognitive avant (au départ) et après la chimiothérapie (environ trois mois). Il s’agira d’une étude prospective sur 50 chirurgies mammaires conservatrices. Nous émettons l’hypothèse que les patientes atteintes d’un cancer du sein qui subissent une chimiothérapie et qui présentent des taux de capacité cardiorespiratoire plus élevés au départ auront des mesures de l’attention, de la fonction exécutive et de la mémoire nettement améliorées après la chimiothérapie. Par ailleurs, les objectifs exploratoires consisteront à examiner les associations longitudinales entre l’activité physique et la fonction cognitive, avant et après la chimiothérapie, et à explorer les associations entre les biomarqueurs inflammatoires et non inflammatoires et la capacité cardiorespiratoire avec la fonction cognitive.

Description de l'essai

Primary Outcome:

  • Fluid Cognition (Composite)
Secondary Outcome:
  • Executive/Attention
  • Executive/Shifting
  • Working Memory
  • Episodic Memory
  • Language
  • Language
  • Processing Speed
  • Crystallized Cognition
  • Immediate Recall
  • Processing Speed
  • Objectively-assessed physical activity
  • Self-reported physical activity
  • Cancer biomarkers
  • Cardiorespiratory fitness
Cognitive impairments are reported as a chief quality of life (QoL) complaint by approximately 75% of breast cancer survivors (BCS). Women who have undergone adjuvant chemotherapy are at the highest risk for cognitive impairments, that may affect BCS up to 20 years post-treatment.Despite the prevalence and significance, it is largely underdiagnosed and there are no proven treatments beyond symptom management. Several studies have assessed cognitive function in cancer populations. Increasing evidence highlights the role of lifestyle behaviours on cancer-related outcomes, ranging from QoL to prognosis. However, very few studies have examined the associations of lifestyle factors and cognitive function in BCS.One of the most important mediators of CRCI in BCS may be cardiorespiratory fitness (CRF). Our overall objective is to examine the behavioural and biological mechanisms that contribute to cognitive decline in BCS undergoing chemotherapy using an epidemiologic, prospective cohort design. Assessments taken at baseline (pre-chemotherapy) and post-chemotherapy (month 3). Cognitive Function will be assessed using the NIH toolbox cognition battery. Physical Activity. PA will be assessed by accelerometers and through self-report using the Godin-Leisure Time Exercise Questionnaire. Cardiorespiratory Fitness will be assessed using the 6-minute walk test to estimate maximum oxygen uptake (VO2max).Cancer Biomarkers will be assessed using venous blood (2 microtubes) will be drawn from the antecubital vein by a trained phlebotomist. Biological markers analyzed in blood will include a multiplex panel of inflammatory cytokines (i.e., IL1, IL6, TNFα), and brain-derived neurotrophic factor (BDNF). Our proposed study will be instrumental in designing future targeted translational lifestyle interventions to improve cognitive health in BCS. In addition, understanding the trajectory of cognitive function as it relates to these factors will determine the opportune timeframe to intervene during the cancer care continuum for the greatest impact

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