The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage II

Official Title

Pioneering Pre- and Post-Operative Integrative Care to Improve Thoracic Cancer Quality of Care - The Thoracic Peri-Operative Integrative Surgical Care Evaluation (POISE) Trial - Stage II

Summary:

Despite enormous advances in thoracic surgery and oncology, two critical issues concern patients undergoing curative-intent surgery for lung, gastric and esophageal cancer: first, a majority (~60%) of patients experience minor and major adverse events occurring during and in the days following surgery; second, patients worry about the significant risk of cancer recurrence and mortality months to years after surgery. These issues, combined with side effects of chemotherapy and radiation, have detrimental effects on health-related quality of life (HRQoL). On a deeper level, there is the problem of an ongoing failure to integrate and evaluate the best of what complementary medicine has to offer surgical oncology care. Too many clinical trials focus on single agent therapies, rather than broad multi-faceted individualized and integrative care interventions that are used in real world settings. The Thoracic POISE project has the overarching goal of improving care for thoracic cancer patients by impacting HRQoL, reducing surgical adverse events, prolonging overall survival and pioneering integrative care delivery.

Trial Description

Primary Outcome:

  • Participant Recruitment Rates
  • Participant Retention Rates
  • Cross-over and contamination in the control arm - Supplement usage
  • Cross-over and contamination in the control arm - Mediterranean Diet Scores
  • Cross-over and contamination in the control arm - Physical Activity levels
  • Cross-over and contamination in the control arm - Psychological Health Activities
Secondary Outcome:
  • Communication
  • Natural Killer Cell Function
  • Qualitative Experience
  • Inflammatory Response
  • Neutrophil to Lymphocyte Ratio

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society