Study of Lymphatic Drainage Mapping in Oropharyngeal Cancers

Official Title

A Feasibility Trial of Lymphatic Mapping With SPECT-CT for Evaluating Contralateral Disease in Lateralized Oropharynx Cancer Using 99m-Technetium Sulfur Colloid


The purpose of the study is to see how practical it is to inject a radiotracer called 99m-Technetium Sulfur Colloid around the tumours for the imaging of patients with oropharyngeal cancer.

Trial Description

Primary Outcome:

  • Proportion of patients injected with radiotracer.
  • Proportion of patients requiring general anesthetic over local anesthetic.
  • Proportion of patients with images that failed radiotracer migration to either side of the neck.
  • Proportion of patients completing 30 minute scan.
  • Proportion of patients completing 3 hour scan.
  • Proportion of patients with radiotracer uptake into a radiographically positive lymph node.
  • Proportion of patients with injections site locations that are compliant with protocol specific map of injection locations.
  • Average time from start to finish of injection of procedure.
  • Proportion of patients with complications associated with injection.
This study will evaluate a technique called lymphatic drainage mapping. This is a technique where a radiotracer (a radioactive material that can be seen with a special computed tomography [CT] scanner to create 3D images) is injected into a vein around the tumour, either with local anesthesia or under general anesthesia. The radiotracer that will be used for the lymphatic drainage mapping is called 99m-Technetium Sulfur Colloid. Images will be taken of neck to detect the movement of the radiotracer. This will allow the doctors to see the drainage pattern of the lymph nodes in the neck. The information from this study will be used to better understand the tendency for oropharyngeal cancers to spread to lymph nodes. In addition, the information from this clinical trial will be used in future clinical studies to help specialists identify strategies to help plan treatment based on this type of imaging study.

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society